Song Liu

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Song Liu is an Associate Professor of Polymer Science & Engineering and directs the Biomaterials Synthesis and Medical Textile Surface Engineering Laboratory at the University of Manitoba in Winnipeg, MB. Dr. Liu earned a Ph.D. in Fiber and Polymer Science at the University of California, Davis.

Dr. Liu‘s research focuses on 1) the development of novel surface engineering techniques for chemically inert semicrystalline polymers; 2) the development of new biocidal and biocompatible materials; and 3) micro- and nano-encapsulation of bioactive agents for their targeted and controlled delivery. He has received over 1.35 M CAD in research funding as PI and close to 1 M CAD as Co-PI or collaborator from various granting agencies (including NSERC, CIHR, CFI and MHRC) for his pioneering work in exploring new durable and versatile surface modification techniques for chemically inert semicrystalline polymers, and developing new broad-spectrum biocides and “smart” polymeric materials. His research group has successfully developed a versatile polyester platform which can allow furnishing the surface with various bio-functionalities via “click” chemistry method in a spatially-controlled manner. This work lays an important foundation for well-controlled durable bio-functionalization of chemically inert semicrystalline polymers for their uses in medical devices such as anti-biofilm catheters, vascular grafts, drug release stents and wound dressings.

Dr. Liu’s research has had successful translation to industry with 5 patent applications, one licensing agreement and a second one in progress. He has won the 2012 Rh Award in Interdisciplinary Studies from the Winnipeg Rh Foundation in view of his leadership in interdisciplinary research.

Biomedical Engineering, Biosystems Engineering
Biomaterials, Biomedical and Electrical Biosensors, Water Resources, Materials Science and Engineering, New Materials and Manufacturing Technologies
Biomaterials, Biocidal surface, Microencapsulation, Nanotechnology, Functional polymers, Biocides
Master Student position, PhD Student position

We are looking for highly self-motivated, intelligent and team-playing students who have a solid background in polymer sciences, chemistry, engineering, and microbiology. You need to be sincerely interested in what we are researching and plan to pursue a Ph.D. or a M.Sc. degree.

Dr. Song Liu‘s research focuses on 1) the development of novel surface engineering techniques for chemically inert semicrystalline polymers; 2) the development of new biocidal and biocompatible materials; and 3) micro- and nano-encapsulation of bioactive agents for their targeted and controlled delivery.

1. Kim, S.; Traore, Y.L.; Ho, E.A.; Liu, S.* Design and development of pH-responsive polyurethane membranes for intravaginal release of nanomedicines. Acta biomaterialia, 2018, in press https://doi.org/10.1016/j.actbio.2018.10.003. (Impact Factor: 6.383).

2. Carta, T.; Gawaziuk, J. P.; Diaz-Abele, J.; Liu, S.; Jeschke M, Logsetty, S.* Properties of an Ideal Burn Dressing: A Survey of Burn Survivors and Front-line Burn Healthcare Providers. Burns, 2018, in press https://doi.org/10.1016/j.burns.2018.09.021. (Impact Factor: 1.904).

3. Ghanbar, S.; Liu S.* New generation of N-chloramine/QAC composite biocides: efficient antimicrobial agent to target antibiotic-resistant bacteria in the presence of organic load. ACS Omega (A new journal launched by ACS in 2016), 2018; 3(8): 9699–9709.
4. Kim, S.; Traore, Y.L.; Ho, E.A.*; Liu, S.* Switchable on-demand release of nanocarrier from a segmented reservoir type intravaginal ring filled with a pH-responsive supramolecular polyurethane hydrogel. ACS Applied Bio Materials (A new journal launched by ACS in 2018), 2018; 1(3): 652–662.
5. Li, W.; Cicek, N.; Levin D.B.; Liu, S.* Enabling electrospinning of medium-chain length polyhydroxyalkanoates (PHAs) by blending with short-chain length PHAs. International Journal of Polymeric Materials and Polymeric Biomaterials, 2018, published online (Impact Factor: 2.127). https://doi.org/10.1080/00914037.2018.1466136
6. Omonijo F, Kim S, Wang Q, Gong J, Nyachoti M, Liu S, Yang C.* Development of novel microparticles for effective delivery of thymol and lauric acid to pig intestinal tract. Journal of Agricultural and Food Chemistry, 2018; 66(37): 9608-9615 (Impact Factor: 3.412).
7. Shek, K.; Patidar, R.; Kohja Z.; Liu, S.; Gawaziuk, J.P.; Gawthrop, M.; Kumar A.; Logsetty, S.* Rate of contamination of hospital privacy curtains in a burns/plastic ward: a longitudinal study. American Journal of Infection Control, 2018; 46(9):1019-21. (Impact Factor: 1.929).
8. Norouzi, M.; Abdali, Z.; Liu, S.; Miller D.* Salinomycin-loaded nanofibers for glioblastoma therapy. Scientific Reports, 2018; 8:9377-86 (Impact Factor: 4.122).
9. Hassan, Y.; Lahaye, L.; Liu, S; Gong, J.; Gay, C.; Peng, J.; Gong, M.; Yang, C.* Innovative drugs, chemicals, and enzymes within the animal production chain: a report from the second alternatives to antibiotics symposium. Veterinary Research, 2018; 49(1):71-87 (Impact Factor: 2.903, cited once).
10. Kim, S.; Liu, S.* Smart biostable polyurethane biomaterials for long-term implantable biomedical application. ACS Biomaterials Science & Engineering, 2018; 4(5): 1479-1490 (Impact Factor: 4.432, times cited: 2).
11. Manna, P.K.; Nickel, R.; Wroczynskyj, Y.; Yathindranath, V.; Li, J.; Liu, S.; Miller, D.W.; van Lierop, J.* Simple, hackable size and shape selective amine-functionalized fe- oxide nanoparticles for biomedical applications. Langmuir, 2018; 34(8): 2778-2757 (Impact Factor: 3.789, cited once).
12. Ghanbar, S.; Fumakia, M.; Ho, E.A.; Liu, S.* A new strategy for battling bacterial resistance: turning potent, non-selectively and potentially non-resistance-inducing biocides into selective ones. Nanomedicine: Nanotechnology, Biology, and Medicine, 2018; 14(2):471-481 (Impact Factor: 6.500, cited one).
13. Kim, S.; Traore, Y.L.; Lee, J.S.; Kim, J.H.; Ho, E.A.*; Liu, S.* Self-assembled nanoparticles made from a new PEGylated poly(aspartic acid) graft copolymer for intravaginal delivery of poorly water-soluble drugs. Journal of Biomaterials Science, Polymer Edition, 2018; 28(17):2082-2099 (Impact Factor: 1.911, times cited: 3).
14. Brichacek, M.; Ning, C.; Gawaziuk, J.P.; Liu, S.; Logsetty, S.* In vitro measurement of burn dressing adherence and the effect of interventions on reducing adherence. Burns, 2017; 43(5):1002-1010 (Impact Factor: 2.134, cited once).
15. Shek, K.; Patidar, R.; Kohja Z.; Liu, S.; Gawaziuk, J.P.; Gawthrop, M.; Kumar A.; Logsetty, S.* Rate of contamination of hospital privacy curtains on a burns and plastic surgery ward: a cross-sectional study. Journal of Hospital Infection, 2017; 96(1):54-58. (Impact Factor: 3.354, times cited: 5).
16. Kim S.; Chen, Y.; Ho, E.A.*; Liu, S.* Reversibly pH-responsive polyurethane membranes for on-demand intravaginal drug delivery. Acta biomaterialia, 2017; 47(1):100-112 (Impact Factor: 6.383, times cited: 12).
17. 19. Kaur, R.; Liu, S.* Antibacterial surface design-contact kill. INVITED REVIEW PAPER. Progress in Surface Science, 2016; 91(3):136-153 (Impact Factor: 9.000, times cited: 24).
18. 20. Rahma, H.; Nickel, R.; Skoropata, E.; Wroczynsky, Y.; Rutley, C.; Manna, P.K.; Hsiao, C.H.; Ouyang, H.; van Lierop, J.; Liu, S.* Quaternized N-chloramine coated magnetic nanoparticles: a trifecta of superior antibacterial activity, minimal residual toxicity and rapid site removal. RSC advances, 2016; 6: 65837-65846 (Impact Factor: 2.936, cited once).
19. Asghari, S.; Logsetty S., Liu S.* Imparting commercial antibacterial dressings with low-adherence to burn wounds. Burns, 2016; 42(4): 877-883 (Impact Factor: 2.134, times cited: 7).
20. Ning, C.; Li, L.; Logsetty, S.; Guo, M.; Ens, W.; Liu, S.* Enhanced antibacterial activity of new “composite” biocides with both N-chloramine and quaternary ammonium moieties. RSC advances, 2015; 5: 93877-93887 (Impact Factor: 2.936, times cited: 8).
21. Silvaa, M.D.; Ning, C.; Ghanbar, S.; Zhanel, G.; Logsetty, S.; Liu, S.; Kumar, A.* Evidence that a novel quaternary compound and its organic N-chloramine derivative do not select for resistant mutants of Pseudomonas aeruginosa. Journal of Hospital Infection, 2015; 91(1): 53- 8 (Impact Factor: 3.354, times cited: 6).
24. Rahma, H.; Asghari, S.; Logsetty, S.; Gu, X.; Liu, S.* Preparation of hollow N-chloramine-functionalized hemispherical silica particles with enhanced efficacy against bacteria in the presence of organic load: Synthesis, characterization and antibacterial activity. ACS Applied Materials & Interfaces, 2015; 7(21): 11536–11546 (Impact Factor: 8.097, times cited: 7).
25. NazariPour, S., Ghugare, S.V.; Wiens, R.; Gough, K; Liu, S.* Controlled in-situ formation of polyacrylamide hydrogel on PET surface via SI-ARGET-ATRP for wound dressings. Applied Surface Science, 2015; 349: 695-704 (Impact Factor: 4.439, times cited: 17).
26. Carta T., Gawaziuk J., Liu S., Logsetty S.* Use of mineral oil fleet enema for the removal of a large tar burn: A case report. Burns, 2014; 41(2):e11-4 (Impact Factor: 2.134, time cited: 2. We found that tar could be easily removed with mineral oil without irritation. Victims of tar burns have benefited and will continue to benefit from this work).
27. Ning, C.; Logsetty, S.; Ghugare S.; Liu, S.* Effect of hydrogel coating, water and surfactant wetting on the adherence of PET dressings. Burns, 2014; 40: 1164-1171. (Impact Factor: 2.134, time cited: 8).
28. Kulkarni, A.; Diehl-Jones, W.; Liu, S.* Layer-by-Layer assembly of epidermal growth factors on polyurethane films for wound closure. Journal of Biomaterials Applications, 2014; 29(2): 278-290. (Impact Factor: 2.082, time cited: 11).
29. Li, L.; Li, J.; Kulkarni, A.; Liu, S.* Polyurethane (PU)-derived photoactive and copper-free clickable surface based on perfluorophenyl azide (PFPA) chemistry. Journal of Material Chemistry B, 2013; 1: 571–582. (Impact Factor: 4.776, time cited: 7).
30. Li, J.; Lin, F.; Li, L.; Li, J.; Liu, S.* Surface engineering of poly(ethylene terephthalate) for durable hemocompatibility via a surface interpenetrating network technique. Macromolecular Chemistry and Physics, 2012; 213(20): 2120–2129. (Impact Factor: 2.492, times cited: 15).
31. He, W.; Gu, X.; Liu, S.* Surfactant-free One-Step Synthesis of Dual-functional Polyurea Microcapsule: Contact Infection Control and Drug Delivery. Advanced Functional Materials, 2012; 22(19): 4023-31. (Impact Factor: 13.325, number of citations: 16).
32. Li, L.; Pu, T.; Zhanel, G.G.; Zhao, N.; Ens, W.; Liu, S.* New Biocide with Both N-Chloramine and Quaternary Ammonium Salt Moieties Exerts Enhanced Bactericidal Activity. Advanced Healthcare Materials, 2012; 1(5): 609-620. (Impact Factor: 5.609, times cited: 27).
33. Li, L.; Zhao, N.; Liu, S.* Versatile surface biofunctionalization of poly(ethylene terephthalate) (PET) by interpenetrating polymerization of a butynyl monomer followed by “click” chemistry. Polymer 2012; 53(1): 67-78. (Journal Impact Factor: 3.684, times cited: 32)
34. Zhao, N.; Logsetty, S.; Liu, S.* Durability of amide N-chloramine biocides to ethylene oxide sterilization. Journal of Burn Care and Research, 2012; 33(4): e201-6 (2015 Journal Impact Factor: 1.923, times cited: 2).
35. Zhao, N.; Liu, S.* Thermoplastic semi-IPN of polypropylene (PP) and polymeric N-halamine for efficient and durable antibacterial activity. European Polymer Journal, 2011; 47 (8): 1654-1663. (Impact Factor: 3.741, number of citations: 33)
36. Zhao, N.; Zhanel, G.G.; Liu, S.* Regenerability of antibacterial activity of interpenetrating polymeric N-halamine and poly(ethylene terephthalate). Journal of Applied Polymer Science, 2011; 120(1): 611–622. (Impact Factor: 1.86, number of citations: 34)
37. Rudenja, S.; Zhao, N.; Liu, S.* Surface Interpenetrating networks of polyacrylamide in poly(ethylene terephthalate) as a means of surface modification. European Polymer Journal, 2010; 46(10): 2078-2084. (Impact Factor: 3.741, number of citations: 17)
38. Liu, S.;* Zhao, N.; Rudenja, S. Surface interpenetrating networks of poly(ethylene terephthalate) and polyamides for effective biocidal property. Macromolecular Chemistry and Physics, 2010; 211(3): 286-96. (Impact Factor: 2.492, number of citations: 41)
39. Liu, S.; Sun, G.* New refreshable N-halamine polymeric biocides: N-chlorination of acyclic amide grafted cellulose. Industrial & Engineering Chemistry Research, 2009; 48(2): 613-618. (Impact Factor: 3.141, number of citations: 58)
40. Liu, S.; Sun, G.* Functional modification of poly(ethylene terephthalate) with an allyl monomer: chemistry and structure characterization. Polymer 2008; 49(24): 5225-5232. (Impact Factor: 3.483, number of citations: 40)
41. Liu, S.; Sun, G.* Biocidal acyclic halamine polymers: conversion of acrylamide-grafted-cotton to acyclic halamine. Journal of Applied Polymer Science, 2008; 108(6): 3480-3486. (Impact Factor: 1.86, number of citations: 20)
42. Liu, S.; Sun, G.* Radical Graft Functional Modification of Cellulose with Allyl Monomers: Chemistry and Structure Characterization. Carbohydrate Polymers, 2008; 71(4): 614-625. (Impact Factor: 5.158, number of citations: 79)
43. Liu, S.; Sun, G.* Durable and Regenerable Biocidal Polymers: Acyclic N-Halamine Cotton Cellulose. Industrial & Engineering Chemistry Research, 2006; 45: 6477-6482. (Impact Factor: 3.141, number of citations: 124)

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